Cathelicidin Antimicrobial Peptides are Expressed in Salivary Glands and Saliva

Cathelicidin antimicrobial peptides are expressed in salivary glands and saliva.

The expression of antimicrobial peptides at epithelial surfaces such as skin, lung, and intestine is thought to provide protection against infection. Cathelicidin antimicrobial peptides are essential for the protection of skin against invasive bacterial infection. To determine if cathelicidins are also present in the oral cavity, we examined the expression of both mRNA and protein in mice and h...

Subacute Sclerosing Panencephalitis, immunological findings in saliva and salivary glands

subacute sclerosing panencephalitis, immunological findings in saliva and salivary glands

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Production of b-Defensin Antimicrobial Peptides by the Oral Mucosa and Salivary Glands

Production of beta-defensin antimicrobial peptides by the oral mucosa and salivary glands.

beta-Defensins are cationic peptides with broad-spectrum antimicrobial activity that are produced by epithelia at mucosal surfaces. Two human beta-defensins, HBD-1 and HBD-2, were discovered in 1995 and 1997, respectively. However, little is known about the expression of HBD-1 or HBD-2 in tissues of the oral cavity and whether these proteins are secreted. In this study, we characterized the exp...